The treatise known as On Theriac to Piso (Περὶ Θηριακῆς πρὸς Πίσωνα), transmitted in the Galenic corpus (ca. 2nd c. CE), is one of the central surviving documents demonstrating:
When read through the strict Greek ritual-mystery lens - without later Christian metaphor - the pharmacological acts in this literature look exactly like initiation technologies: controlled venom exposure, youth-training, vision-induction, and body-salving (christing) rites.
These form the cultural backdrop against which the Markan νεανίσκος (young pubescent male in the σίνδων in the Garden of Gethsemanie) and the Echidnaic female venomic oracles become fully intelligible.
This article lays out the chain of evidence.
The older Greek pharmacological horizon already operated with a binary contrast between θανάσιμον (thanasimon) and γαλήνη (galene) — the death-bearing and the calming. Hippocratic writers define thanasima pharmaka as “the drugs of serpents” (De morbis 4.32), a classification elaborated by Nicander, who calls certain reptiles “creatures whose bites are death-bearing” (Ther. 22–25), and by Galen, who states plainly that “snake-venom is death-bearing” (Antid. 1.6).
Against these stood the agents of γαλήνη (galene), restoring bodily and psychic stillness: Dioscorides notes a root that “provides calm and quiet to the body” (Mat. med. 1.64), and Galen describes gentle, cooling antidotes that “lead the body toward calm” (Temp. 2.4).
Mystery-cult language mirrors this polarity. In the PGM one asks a deity to “grant calm” after incited frenzy (PGM IV.578), and Euripides’ Bacchae dramatizes the turning of the initiate’s ēthos “toward calm” (1000–1005). Thus already before the high era of theriac, the Greek pharmakon world was structured around venom and its counterforce—θανάσιμον (thanasimon) as ordeal, γαλήνη (galene) as the restoration of balance, precisely the ritual arc preserved in Echidnaic and Asclepian praxis.
So, Before theriac (θηριακή) emerges as the master panacea drug, Greek pharmacology operated with a binary pattern:
Sounds harsh to "induce death" on purpose, why?
Because near death experience (NDE) is broadly associated with causing a mystical experience , to heal the soul and psyche.
It was harsh by design: a technology to induce NDE for the purpose of molding a better person.
NDE is also very risky. So having a technology to control the experience while minimizing harm, is ideal.
Healing through education of the soul and psyche was thought to heal the body, for a time, at Asclepian medical centers. Which was basis of Asclepian medicine until Galen started pruning the Hippocratic corpus of its less science-based material.
The Greek pharmacological tradition transitions through two broad phases:
History
An initiate is given just enough from the venom components to produce the aionic effect, then enough galenic agents to recover.
While direct textual evidence is fragmentary at this early horizon, Greek mythic memory preserves these pharmakon traditions in recognizable form.
The universal antidote containing both thanasimon and galene elements:
History
Theriac is storm + calm in one body, an engineered balanced ecstatic pharmakon.
Theriac would be a universal rite-drug, all in one, providing it's own Galene.
At TLG, we see ~287 hits for θανάσιμα and friends:
We now reach the treatise itself: On Theriac to Piso.
The Piso family (esp. Gnaeus Calpurnius Piso, d. 20 CE) was deeply entangled in political scandals involving:
The female rite (Echidnaic, drakaina tradition) centers on:
The Echidna, as temple priestess, is described in the Acts of Philip as:
δρακαίνη, “she-dragon,” “mother of serpents” — an obvious Greek cultic marker of venom-priestesses.
The Theriac tradition connects directly to this female pharmakon lineage: same venoms, same salves, same mixing.
If the Echidnaic rites represent the female line of venom and vision, the Heraclean cycle preserves the male initiation rite - a rite already corrupted in antiquity. Heracles is the first hero to appropriate the Echidnaic venom-rite for male use, establishing a pattern later echoed in the Markan νεανίσκος: a youth in a dangerous pharmakon drama with an older “master.”
But long before the Gospels, the template exists in the Bronze-Iron Age pharmakon culture of the Black Sea, preserved unambiguously in Herodotus.
Herodotus recounts that during Heracles’ wandering among the Scythians—those whom the Greeks call “Σκύθαι,” though they call themselves “Σκολότοι”—the hero strayed in winter into a dense forested region called the Hylaia. There, searching for his lost horses, he entered an ἄντρον, a sacred cave. Inside he met a mixoparthenos, a “two-formed” Echidnaic woman-serpent:
εὑρεῖν ἐν ἄντρῳ μιξοπάρθενον τινά,
ἔχιδναν διφυέα,
τῆς τὰ μὲν ἄνω ἀπὸ τῶν γλουτῶν εἶναι γυναικός,
τὰ δὲ ἔνερθε ὄφιος.
He found in a cave a certain mixoparthenos, an ἔχιδναν (Echidna) of double nature, whose upper parts from the buttocks up were of a woman (γυναικός), and whose lower parts were serpent (ὄφιος).
When Heracles asks about his horses, she replies with cultic authority:
ἔχω τὸ κράτος.
οὐκ ἀποδώσω πρὶν ἢ οἱ μιχθῇς.
I hold the power. I will not give them back until you have intercourse with me.
Here the female venom-priestess asserts κράτος (kratos) - ritual power - over the intruding male.
This is the oldest surviving description of a male entering a forbidden female pharmakon space and being compelled to undergo the sexual-venom rite.
Herodotus gives no name. But, there are three plausible identities:
All three interpretations converge on a single truth:
Heracles walked into the chamber of a female serpent-priestess whose authority exceeded his own. She controlled the rite. He submitted.
This is the core of the male pharmakon initiation.
After the mixoparthenos compels Heracles into ritual intercourse, she bears him three sons
Heracles goes on to:
This constellation reveals a mythic pattern:
Heracles systematically seizes the tools, symbols, and pharmaka of the Echidnaic order.
He becomes, in Greek memory, the first male figure who forcibly appropriates the venom-mastery previously guarded by Echidnaic priestesses, by explicitly destroying or dominating the female and centauric custodians of the rite.
The first male “venom-master”
Heracles surrounds himself with neaniskos pubescent young males:
Ancient sources (Diodorus, Pindar, scholia) preserve the pattern of:
In the literary tradition, Medea is the only woman permitted to purify, inspect, or heal Heracles after pharmakon-related ordeals (e.g., Euripides Heracles; Apollodorus 2.4–2.5). This establishes her as the sole female figure with authority in his pharmacological cycle.
Even his madness cannot be cured by men - only by the Colchian pharmakis, the senior Medwa.
This pattern matches:
Mixoparthenos -> Medwa -> Medea -> the only woman allowed into the Heraclean mysteries.
Iolaus participates in Heracles’ pharmakon-rite (Hydra venom episode)
Ἰόλαος δὲ πυρσὸν ἐνέγκας ἐπέκαιε τὰς τραχήλους,
“And Iolaus, bringing a firebrand, burned the neck-stumps.”
Iolaus is literally a neaniskos (νεανίσκος) assisting in venom-handling — preventing the Hydra’s toxic regeneration while Heracles harvests the serpent’s deadly blood.
Ἰόλαον δ᾽ ἔτι τελετᾶν τιμαί.
“And Iolaus still receives rites of honor.”
ἐγένετο δὲ αὐτῷ παῖς Ὕλλος.
“And there was born to him a child, Hyllus.”
Χείρων δὲ αὐτὸν ἐδίδασκε γράμματα καὶ κιθάραν καὶ θήραν.
“And Chiron taught him letters, the lyre, and hunting.”
Χείρων τὸν Ἀσκληπιὸν ἐδίδαξε φάρμακα πολλὰ καὶ ἐπ᾽ ἀνδράσιν ἰᾶσθαι.
“Chiron taught Asclepius many pharmaka and how to heal men.”
Χείρων δὲ τοὺς παῖδας ἤγειρε καὶ ἐπαίδευσεν.
“Chiron raised and educated the boys.”
Λῖνος δ᾽ ἔπαιζε τὴν κιθάραν Ἡρακλεῖ.
“And Linus played (taught) the lyre to Heracles.”
Λῖνον ὁ Ἡρακλῆς παίων τῇ κιθάρᾳ ἀπέκτεινεν.
“Heracles struck Linus with the lyre and killed him.”
Χείρων ἔτρεφε καὶ ἐπαίδευσεν, ἰητρικῆς δὲ ἔδωκεν ἔμπειρον.
“Chiron raised and instructed him, and gave him skill in the medical art.”
This does not name Heracles, but Chiron’s curriculum is identical across pupils (Heracles, Achilles, Asclepius).
Thus Heracles is implicitly taught:
This is directly attested - Heracles receives Gorgon blood from Athena.
Athena gave to Heracles the blood of the Gorgon:one part healing for men, the other deadly.
Gorgon blood = Echidnaic / Medean venom healing = aionic/healing pharmakon
Chiron centaurus, sapientissimus omnium et medicus.
“Chiron the centaur — wisest of all and a healer.”
ἔνθα Χείρων ἔννεπε Πηλείδᾳ,
φάρμακα τ᾽ ἀλφιτόεντα καὶ ἱατρῶν τέχνας,
καὶ μαντοσύναν ἀνθρώποισιν.
There Chiron spoke to the son of Peleus, teaching him the healing pharmaka, and the arts of physicians, and prophetic knowledge for humankind.
Links Chiron with medical-pharmakon initiation AND prophetic rites.
Χείρων γὰρ ἐπαίδευσεν Ἡρακλέα καὶ τοὺς ἄλλους ἥρωας,
ἰατρικῆς τε καὶ μουσικῆς καὶ παντοίων ἀρετῶν.
“For Chiron educated Heracles and the other heroesin medicine, and in music, and in all manner of virtues.”
Chiron teaches medicine to Heracles and all heroes.
These passages establish Chiron as the pagan magus archetype — the prototype of the “magi” in later traditions.
ὦ παῖ, λέγω σε τἀμὰ πάντα κληρονομεῖν·
ὅσσ᾽ ἐγὼ πέπονθα καὶ πεπράχ᾽, ἔμπεδον φέρε·
ἀντὶ δ᾽ ἐμοῦ γενήσῃ φανερὸς Ἡρακλέους.
O child, I tell you: you inherit all that is mine —all that I have suffered and all that I have done, bear them steadfastly; and in my place you shall appear as Heracles’ true successor.
Ὕλλος δὲ ὁ παῖς Ἡρακλέους καὶ Δηϊάνειρας
ἔλαβε τὴν βασιλείαν κατὰ τὰ πάτρια.
“And Hyllus, the son of Heracles and Deianeira,received the kingdom according to ancestral custom.”
We now reconstruct the Markan νεανίσκος from Mark 14:51 in light of all of this.
νεανίσκος (neaniskos) = a very young male, classed by Hesychius (5th c. CE) not as an adult “youth” but as a νήπιος, e.g., a child or small boy not yet mature. Classed by Philo (45 BCE) as a just-pubescent boy.
In the lexicon of Hesychius (5th c. CE), the term νεανίσκος is explicitly equated with νηπίος (“a small child, a very young one, one not yet mature”). Hesychius further defines νηπίον as νεόγυον, νεώτερον, μικρόν — “newborn, very young, small” as a range. Thus, by Hesychius, νεανίσκος cannot denote an adult or late teen, but belongs to the semantic field of childhood and early boyhood, extending at most to the liminal years approaching ἥβη.
Hesychius tells us that a neaniskos is, quite literally, a νήπιος — a child, a “small one,” not yet at the stage of full ἥβη.
From Vol II, page 700
νεανίσκος· νήπιος
Neaniskos: nepios (a child, one not yet mature)
From Vol II, page 710
νηπίον· νεόγυον, νεώτερον, μικρόν (E 480) gn. ἀνόητον, ἄφρον, ἢ ἀφρονεστάτον gn
Nēpion: newborn (νεόγυον), very young (νεώτερον), small (μικρόν). Generally: without understanding (ἀνόητον) senseless/foolish (ἄφρον) or most foolish (ἀφρονεστάτον).
Crucially, Hesychius glosses νεανίσκος (neaniskos) with νήπιος (nepios), demonstrating that the Markan νεανίσκος (neaniskos) cannot be a “late teen,” but is a small boy or early-pubescent youth (mikron (μικρόν) is small, typically 5-13 yrs is the growth stage for a boy), linguistically grouped with children who are not yet of ἥβη (puberty maturity). This perfectly fits the profile of early initiands in Greek pharmakon- and venom-based rites.
Accordingly, the Markan νεανίσκος is not a “youthful young man,” but a very young boy, one not yet fully mature, precisely the type used in certain Greek ritual and initiatory contexts.
This definition aligns with Greek usage where νεανίσκος is a diminutive form (-ίσκος) indicating smallness, youth, and immaturity, in contrast to νεανίας (an adolescent or young man).
And also aligns with Philo of Alexandria's 7 stages of life where neaniskos is aligned with biological maturity of "just fertile".
In medical Greek, σίνδων is a fine linen bandage, absorbing liquids.
This matches pharmacological practice: binding a pharmakon against the skin to induce slow absorption (Galen uses επιθέματα (epithemata) for similar function).
The reading for each term here, is consistent with the later context from the punishment by crucifixion scene. Considering the Oxos on a Sponge, extreme thirst, and early coma well before any of the other Lestes criminals passed out on their cross, it would appear Jesus was under the influence of dipsas venom.
Matches the venom-induced altered state pattern described by Galen (“vivid visions”), Nicander, and the PGM.
καὶ ἐξελθοῦσαι ἔφυγον ἀπὸ τοῦ μνημείου· εἶχεν γὰρ αὐτὰς φόβος καὶ ἔκστασις· καὶ οὐδενὶ οὐδὲν εἶπαν· ἐφοβοῦντο γάρ.
And having gone out, they fled from the tomb;
for fear and ecstasy possessed them;
and they said nothing to anyone,
for they were afraid.
This is the famous abrupt ending of Mark - the women flee in φόβος καὶ ἔκστασις, “fear and ecstasy / trance,” consistent with the mystery-cult and pharmakon-induced visionary framing.
The pairing φόβος + ἔκστασις is a characteristic mystery-language dyad.
Mark’s ending uniquely combines these two to signal that the women’s flight is not mundane panic but the onset of an altered state — precisely the lexicon used in initiatory Greek texts describing the liminal threshold between ordinary consciousness and the pharmakon-induced vision-space.
Greek toxicology recognized:
Thus the Markan youth appears as a member of a male mystery cell using applied theriac-like pharmaka, possibly a survivor fleeing from an interrupted nocturnal rite.
We now have the full evidentiary chain, demonstrating that On Theriac to Piso is not an isolated medical curiosity but part of a long Greek tradition with ritual implications:
Therefore:
The Greek pharmacological record—literary, medical, ethnographic, and political—supports a coherent reconstruction of male initiation rites involving venom-conditioning (Markan νεανίσκος), and female oracle rites in the Echidnaic tradition, both grounded in the same pharmakon technologies codified in Theriac to Piso.